1.Identification 1.1 GHS Product identifier Product name phenylhydrazine 1.2 Other means of identification Product number - Other names Fenilidrazina [Italian] 1.3 Recommended use of the chemical and restrictions on use Identified uses For industry use only. Intermediates Uses advised against no data available 1.4 Supplier's details 1.5 Emergency phone number Emergency phone number - Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). 2.Hazard identification 2.1 Classification of the substance or mixture Acute toxicity - Oral, Category 3
Acute toxicity - Dermal, Category 3
Skin irritation, Category 2
Eye irritation, Category 2
Skin sensitization, Category 1
Acute toxicity - Inhalation, Category 3
Germ cell mutagenicity, Category 2
Carcinogenicity, Category 1B
Specific target organ toxicity – repeated exposure, Category 1
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
2.2 GHS label elements, including precautionary statements Pictogram(s) Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H311 Toxic in contact with skin
H315 Causes skin irritation
H319 Causes serious eye irritation
H317 May cause an allergic skin reaction
H331 Toxic if inhaled
H341 Suspected of causing genetic defects
H350 May cause cancer
H400 Very toxic to aquatic life
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P271 Use only outdoors or in a well-ventilated area.
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
Response P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P312 Call a POISON CENTER/doctor/…if you feel unwell.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
P333+P313 If skin irritation or rash occurs: Get medical advice/attention.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P311 Call a POISON CENTER/doctor/…
P308+P313 IF exposed or concerned: Get medical advice/ attention.
P314 Get medical advice/attention if you feel unwell.
P391 Collect spillage.
Storage P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal P501 Dispose of contents/container to ...
2.3 Other hazards which do not result in classification none
3.Composition/information on ingredients 3.1 Substances Chemical name Common names and synonyms CAS number EC number Concentration phenylhydrazine phenylhydrazine 100-63-0 none 100% 4.First-aid measures 4.1 Description of necessary first-aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled Fresh air, rest. Refer for medical attention.
In case of skin contact Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
In case of eye contact First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed Material is corrosive to tissue. Exposure can cause vomiting, diarrhea, fatigue, headache, and irritation and itchiness of the eyes and skin. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary Specific treatment for exposure consists of thorough washing of all exposed skin areas with soap and water, copious irrigation of the eyes, and prompt removal of the patient from the source of exposure. /Hydrazines/
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing media Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)
5.2 Specific hazards arising from the chemical Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as nitrogen oxides and carbon monoxide, may be formed when involved in fire. Behavior in Fire: May ignite spontaneously when spread on a large surface or when in air and in contact with porous materials such as soil, asbestos, wood, or cloth. (USCG, 1999)
5.3 Special protective actions for fire-fighters Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions Evacuate danger area! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. If liquid: collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. If solid: sweep spilled substance into containers. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
7.Handling and storage 7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities Separated from strong oxidants and food and feedstuffs. Store in an area without drain or sewer access.Keep well closed and protected from light
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit values NIOSH considers phenylhydrazine to be a potential occupational carcinogen.
Recommended Exposure Limit: 2 Hr Ceiling value: 0.14 ppm (0.6 mg/cu m), skin.
Biological limit values no data available
8.2 Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection Wear dust mask when handling large quantities.
Thermal hazards no data available
9.Physical and chemical properties Physical state yellow to pale brown oily liquid Colour Monoclinic prisms or oil Odour Faint, aromatic odor. Melting point/ freezing point 112°C(lit.) Boiling point or initial boiling point and boiling range 272°C Flammability Class IIIA Combustible Liquid: Fl.P. at or above 60°C and below 93.33°C. Combustible SolidCombustible. Gives off irritating or toxic fumes (or gases) in a fire. Lower and upper explosion limit / flammability limit no data available Flash point 88°C(lit.) Auto-ignition temperature 173.89°C (USCG, 1999) Decomposition temperature 243.5°C pH no data available Kinematic viscosity no data available Solubility In water:145 g/L (20 oC) Partition coefficient n-octanol/water (log value) log Kow= 1.25 Vapour pressure <0.1 mm Hg ( 20 °C) Density and/or relative density 1.099 Relative vapour density 4.3 (vs air) Particle characteristics no data available 10.Stability and reactivity 10.1 Reactivity no data available
10.2 Chemical stability Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions Flammable when exposed to heat, flame, or oxidizers.PHENYLHYDRAZINE may ignite spontaneously when in contact with oxidants such as hydrogen peroxide or nitric acid, oxides of iron or copper, or manganese, lead, copper or their alloys. Will not polymerize (USCG, 1999).
10.4 Conditions to avoid no data available
10.5 Incompatible materials Strong oxidizers, lead dioxide.
10.6 Hazardous decomposition products When heated to decomposition it emits highly toxic fumes of /nitrogen oxides/.
11.Toxicological information Acute toxicity Oral: LD50 Rat oral 188 mg/kg Inhalation: no data available Dermal: no data available Skin corrosion/irritation no data available
Serious eye damage/irritation no data available
Respiratory or skin sensitization no data available
Germ cell mutagenicity no data available
Carcinogenicity A3; Confirmed animal carcinogen with unknown relevance to humans.
Reproductive toxicity no data available
STOT-single exposure no data available
STOT-repeated exposure no data available
Aspiration hazard no data available
12.Ecological information 12.1 Toxicity Toxicity to fish: LC50 Brachydanio rerio (Zebrafish) 0.16-0.26 mg/L/96 hr /Conditions of bioassay not specified in source examined Toxicity to daphnia and other aquatic invertebrates: no data available Toxicity to algae: no data available Toxicity to microorganisms: no data available 12.2 Persistence and degradability In a Warburg respirometer study using aniline-acclimated activated sludge, phenylhydrazine was found to be appreciably more resistant to biological oxidation than aniline(1). Phenylhydrazine, in the static Zahn-Wellens test, was 85% biodegraded in 9-13 days; circa 25% biodegradation of this compound was reported for other laboratories using respirometer tests(2).
12.3 Bioaccumulative potential An estimated BCF value of 2 was calculated for phenylhydrazine(SRC), using a measured log Kow of 1.25(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil The Koc of phenylhydrazine is estimated as approximately 110(SRC), using a measured log Kow of 1.25(1) and a regression-derived equation(2). According to a recommended classification scheme(3), this estimated Koc value suggests that phenylhydrazine has high mobility in soil(SRC). The pKa of phenylhydrazine has been reported as 5.21(4), suggesting this compound exists as a cation in moist soils, and cations tend to adsorb more to soils than neutral compounds(5).
12.5 Other adverse effects no data available
13.Disposal considerations 13.1 Disposal methods Product The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN Number ADR/RID: UN2572 IMDG: UN2572 IATA: UN2572 14.2 UN Proper Shipping Name ADR/RID: PHENYLHYDRAZINE IMDG: PHENYLHYDRAZINE IATA: PHENYLHYDRAZINE 14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1 14.4 Packing group, if applicable ADR/RID: II IMDG: II IATA: II 14.5 Environmental hazards ADR/RID: yes IMDG: yes IATA: yes 14.6 Special precautions for user no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code no data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question Chemical name Common names and synonyms CAS number EC number phenylhydrazine phenylhydrazine 100-63-0 none European Inventory of Existing Commercial Chemical Substances (EINECS) Listed. EC Inventory Listed. United States Toxic Substances Control Act (TSCA) Inventory Listed. China Catalog of Hazardous chemicals 2015 Listed. New Zealand Inventory of Chemicals (NZIoC) Listed. Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed. Vietnam National Chemical Inventory Not Listed. Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed. 16.Other information Information on revision Creation Date Aug 10, 2017 Revision Date Aug 10, 2017 Abbreviations and acronyms
CAS: Chemical Abstracts Service ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road RID: Regulation concerning the International Carriage of Dangerous Goods by Rail IMDG: International Maritime Dangerous Goods IATA: International Air Transportation Association TWA: Time Weighted Average STEL: Short term exposure limit LC50: Lethal Concentration 50% LD50: Lethal Dose 50% EC50: Effective Concentration 50%
References IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/ eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp ECHA - European Chemicals Agency, website: https://echa.europa.eu/ Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.